Projects

All our projects are available on clinicaltrials.gov

Ovo r&d is continuously proposing new studies in various fields:

  • Fertility

  • Inseminations;

  • In vitro fertilization;

  • Fertility preservation

  • Menopause;

  • Endometriosis;

  • Painful menstruation;

  • Fibroids;

  • Urinary incontinence;

  • Vaginal dryness;

  • Sexually transmitted infections;

  • Heavy bleeding;

  • Irregular menstrual cycles;

  • Pregnancy.

Ongoing Projects

Fertility projects

Fertility preservation - Ooxyd study

Correlation of oxidative stress and oocyte quality in fertility preservation

Principal investigator: Dr Jacques Kadoch, MD

Fellow responsible: Dr Walaa Yamout, MD

Sponsor: Ovo Fertility Ferring Pharmaceuticals

Description: The quality of the oocytes is determining to have a pregnancy. Two important factors influence this quality: The stimulation medications taken to obtain eggs to be collected and the oxidative stress in your cells. Studies have shown that oxidative stress is associated to poor quality oocytes. It is therefore necessary to understand the importance of the effect of oxidative stress on oocyte quality and to use effective treatments. This would help your doctor in the future to improve the quality of the oocytes to be preserved to increase the chances of a future pregnancy.

Number of participants wanted: 180

Participating sites :

  • clinique ovo, Montreal, Québec
  • Ottawa Fertility Center, Ottawa, Ontario
  • Olive Fertility Center, Vancouver, British Columbia

Study coordinator: Marya Far

For more information on this research project, you can contact the person in charge of the project at 514 798 2000 ext. 761 or by email l.joseph@cliniqueovo.com

In Vitro fertilization – Polycystic Ovary Syndrome

Effect of hyperandrogenism on IVF success rates in PCOS patients

 

Principal Investigator: Dr Joanne Benoit, MD

Fellow responsible: Dr Ali Mourad, MD

Sponsor: ovo fertility

Description: Androgen hormones excess (hyperandrogenism) is an important feature of PCOS. It is often present in patients with PCOS condition and can affect the quality of oocytes and embryos. It is important to determine whether hyperandrogenism has an impact on the success of IVF. This would help physicians predict fertility prognosis based on the characteristics of each condition and possibly improve IVF outcomes

Number of participants sought: 188 patients

Project coordinator: Marya Far

For more information on this research project, you can contact the person in charge of the project at (514) 798-2000 ext. 761 or at m.far@cliniqueovo.com.

Frozen Embryo Transfer (FET) - P4R study

P4R: Rescue progesterone supplementation in patients with low progesterone on the day of embryo transfer for artificial endometrial preparation cycles: a pilot study.

Principal investigator: Dr Wael Jamal

Fellow responsible: Dr Karen Kteily

Investigator PIBF portion: Dr Jacques Kadoch

Sponsor: Ovo fertility

in collaboration with: Ferring pharmaceuticals

 

A special interest for the impact of serum progesterone levels measured on the day before or the day of frozen embryo transfer (FET) has arisen in recent years. The progesterone, a female hormone that serves to prepare the uterus for pregnancy, has proven its crucial role in human reproduction on many levels. Some studies have shown that when the progesterone level is low there would be an increased risk of miscarriage.

 

Thus, the aim of this research project is to assess whether a high dose of Endometrin after a FET could improve the rate of ongoing pregnancy and thus prevent premature miscarriages. We therefor suggest that a woman with low progesterone level, determined by a blood test on the day of FET, should benefit from a daily dose of 600 mg of Endometrin. While women with an adequate blood level of progesterone according to the literature and the research protocol, will continue with the usual dose of Endometrin, 300 mg per day.

 

Number of participants wanted: 150

 

Clinical trials: NCT05555121

 

 

Study coordinator: Lindsay Joseph - For more information on this research project, you can contact us at (514) 798-2000 ext. 756 or at m.roberge@cliniqueovo.com 

Projects in general gynecology

Prenatal projects

Recruitment completed

OASIS menopause (recruitment completed)

Currently analyzing the data.

 

To evaluate the efficacy and safety of an HORMONE- FREE (BAY 3427080) medication in reducing hot flashes associated with menopause

 

Principal Investigator: Dr. Talya Shaulov

 

Sponsor: Bayer pharmaceuticals

Number of participants sought: 7

FIT FOR FERTILITY (recruitment completed)

Currently analyzing the data.

 

The objective of the study is to evaluate the effects of a lifestyle management program on fertility for patients with infertility and obesity

This study is being conducted in collaboration with the CHUM and Sherbrooke university.

 

Principal Investigator: Dr. Jean-Patrice Baillargeon - Sherbrooke university

Visit location: CHUM

Sponsor: Sherbrooke university

Number of participants sought: 616 (multicentric)

IUI scratching (recruitment completed)

Currently analyzing the data.

 

Randomized controlled trial of the impact of uterine scratching prior to intrauterine insemination in unexplained infertility.

 

Principal Investigator: Dr Louise Lapensée, MD

Sponsor: ovo fertility

Description: Among the possible medical treatments in assisted reproduction for couples concerned by unexplained infertility, several methods can be considered, including firstly increasing the number of oocytes by ovarian stimulation and synchronizing intrauterine insemination (IUI) of sperm during ovulation. Most of the time, this involves ovarian stimulation with clomiphene citrate, tamoxifen, letrozole and/or gonadotropin, possibly followed by an IUI. However, an emerging medical practice, endometrial scratching, would be beneficial to couples whose infertility is unexplained. This corresponds to the performance of a microtrauma of the endometrium using a pipelle de Cornier. This procedure is recognized in IVF for women with repeated unexplained implantation failures because it increases pregnancy rates.

Number of participants sought: 197 patients per cohort for a total of 394, single-centre recruitment at clinique ovo.

adhesioRT - Frozen embryon transfer (recruitement completed)

Currently analyzing the data.

 

Customization of the implantation window during frozen embryo transfer.

 

Principal Investigator: Dr. Jacques Kadoch

Sponsor: ovo fertility

Collaboration with: Ferring pharmaceuticals

Description: The objective of the project is to compare standard substituted cycle frozen embryo transfer (SCET) with substituted SCET using the adhesioRT test to determine when the endometrium is receptive to receive the frozen embryo. The costs associated with the adhesioRT test procedures will be covered if you are part of the research project.

Number of participants: 120

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